Tuberculosis resistente a múltiples medicamentos

Manuel Alvarez-Gaviria, Fernando De la Vega-Del Risco, Ariel Bello-Espinosa, Merle Lora-Hurtado, Diana Navas-Torrejano, Cherina Herazo-Bustos

Resumen


Introducción: la tuberculosis (TB) pulmonar es un problema creciente de salud

mundial y la resistencia a los antibióticos un elemento de preocupación.

Caso clínico: paciente de 19 años, quien ingresó al servicio de urgencias por presentar hemoptisis. Antecedente de TB con tratamiento irregular. Se documentó resistencia a varios medicamentos. Se consideraron las diferentes estrategias de tratamiento disponible. Debido al elevado riesgo epidemiológico y la historia de pobre adherencia al tratamiento, se realizó manejo intrahospitalario con respuesta satisfactoria.

Conclusiones: la tuberculosis multirresistente (MDR-TB) representa un riesgo para la comunidad, teniendo en cuenta la vía de transmisión de la entidad. Rev.cienc. biomed. 2013;4(1):159-164

 

PALABRAS CLAVES

Tuberculosis pulmonar; Tuberculosis resistente a múltiples medicamentos; Antituberculosos.

 

SUMMARY

Introduction: tuberculosis is an increasing problem of global health and the microbial drug resistance a generating element of worry.

Clinical case: 19 year-old patient, who admitted to the emergency room for presenting hemoptysis and who had history of pulmonary tuberculosis with irregular treatment. Multidrug-resistant tuberculosis was documented and different strategies of available medical treatment were considered. Due to the increased epidemiological risk and the history of poor adherence to the treatment, an in-hospital treatment was carried out with a satisfactory response.

Conclusion: multidrug-resistant tuberculosis is a social risk, keeping the route of transmission of the disease. Rev.cienc.biomed. 2013;4(1):159-164

KEYWORDS

Tuberculosis; Multidrug-resistant uberculosis; Antitubercular Agents.


Citas


The Lancet Infectious D. The worldwide epidemic of multidrug-resistant tuberculosis. The

Lancet infectious diseases. 2011;11(5):333.

Hafkin J, Modongo C, Newcomb C, Lowenthal E, MacGregor RR, Steenhoff AP, et al. Impact

of the human immunodeficiency virus on early multidrug-resistant tuberculosis treatment

outcomes in Botswana. Int J Tuberc Disease. 2013;17(3):348-353.

Spigelman M, Compton C, Gheuens J. Multidrug-resistant tuberculosis. The NEngl J Med.

;367(22):2155.

Migliori GB, D’Arcy M, Sotgiu G, Lange C. Multidrug-resistant and extensively drug-resistant

tuberculosis in the West. Europe and United States: epidemiology, surveillance, and control.

Clinics in chest medicine. 2009;30(4):637-665.

Prasad R. Multidrug and extensively drug-resistant tuberculosis management: Evidences and

controversies. Lung India. 2012;29(2):154-159.

Bernal E, Munoz A, Nunez ML, Cano A. Multidrug-resistant spinal tuberculosis and giant

paraspinal abscesses. Med Clin. 2012;138(4):184.

Kritski AL. Multidrug-resistant tuberculosis emergence: a renewed challenge. J braspneumol.

;36(2):157-158.

Ferro BE, Nieto LM, Rozo JC, Forero L, van Soolingen D. Multidrug-resistant Mycobacterium

tuberculosis, Southwestern Colombia. EmergInfect Dis . 2011;17(7):1259-1262.

Imperiale BR, Zumarraga MJ, Weltman G, Zudiker R, Cataldi AA, Morcillo NS. First evaluation

in Argentina of the GenoType(R) MTBDRplus assay for multidrug-resistant Mycobacterium

tuberculosis detection from clinical isolates and specimens. Rev Argent Microbiol.2012;44(4):283-289.

Martínez-Guarneros A, Rastogi N, Couvin D, Escobar-Gutiérrez A, Rossi LM, Vázquez-Chacón

CA, et al. Genetic diversity among multidrug-resistant mycobacterium tuberculosis strains in

Mexico. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary

genetics in infectious diseases. 2013;14:434-443.

Kalokhe AS, Shafiq M, Lee JC, Ray SM, Wang YF, Metchock B, et al. Multidrug-resistant

tuberculosis drug susceptibility and molecular diagnostic testing. The American Journal of the

Medical Sciences. 2013;345(2):143-148.

Palmero DJ, Ambroggi M, Brea A, De Lucas M, Fulgenzi A, Martínez D, et al. Treatment and

follow-up of HIV-negative multidrug-resistant tuberculosis patients in an infectious diseases

reference hospital, Buenos Aires, Argentina. The international journal of tuberculosis and lung

disease 2004;8(6):778-784.

Mitnick CD, Franke MF, Rich ML, Alcantara Viru FA, Appleton SC, Atwood SS, et al. Aggressive

regimens for multidrug-resistant tuberculosis decrease all-cause mortality. PloS one.

;8(3):e58664.

Torralba-González M, Méndez R, Guerra A, Rodríguez M. Protocolo terapéutico de la tuberculosis

multirresistente. Medicine. 2010;10(56):3856-3859.

Fortún J, Martín-Dávila P, Rodríguez JM, Navas E, Moreno S. Infección por Mycobacterium

tuberculosis. Medicine. 2010;10(56):3808-3819.

Wilson M. Recent Advances in the Laboratory Detection of Mycobacterium tuberculosis Complex

and Drug Resistance. Clinical Infectious Diseases. 2011;52(11):1350-1355

Pelly T, Moore D, Gilman R, Evans C. Recent tuberculosis advances in Latin America. Current

Opinion in Infectious Diseases 2004,17:397-403

Chan E, Iseman M. Multidrug-resistant and extensively drug-resistant tuberculosis: a review.

Current Opinion in Infectious Diseases. 2008,21:587–595.

LoBue P. Extensively drug-resistant tuberculosis. Current Opinion in Infectious Diseases. 2009,

:167–173

Nyendak M, Lewinsohn D, Lewinsohn D. New diagnostic methods for tuberculosis. Current

Opinion in Infectious Diseases. 2009,22:174–182

Migliori GB, D’Arcy Richardson M, Sotgiu G, Lange C. Multidrug-resistant and extensively drugresistant

tuberculosis in the west Europe and United States: epidemiology, surveillance and

control. Clin Chest Med. 2009;30:637–665.

Navas E, Moreno S. Tuberculosis multirresistente y extremadamente resistente. Rev

EspSanidPenit. 2010;12:91-98

Sánchez F, López J, Villarino E, Grosset J. New drugs for tuberculosis treatment.

EnfermInfeccMicrobiolClin. 2011;29(Supl 1):47-56.


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Revista Ciencias Biomédica

Departamento de Investigaciones

Facultad de Medicina, Universidad de Cartagena

Editor: Dr. Alvaro Monterrosa

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